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Advise sufferers that: Tramadol Hydrochloride Extended-Release is for oral use only and should be swallowed full. The capsule really should not be chewed, dissolved, crushed or split. Tramadol Hydrochloride Extended-Release might cause seizures and/or serotonin syndrome with concomitant utilization of serotonergic agents (together with SRIs, NRIs,